Description
Non-alcoholic fatty liver disease (NAFLD) includes two morphological forms that differ significantly in prognosis: non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). The progression of steatosis to steatohepatitis with subsequent development of fibrosis and cirrhosis is associated with a genetic aberration in the PNPLA3 gene. The I148M mutation in this gene causes a disturbance in triglyceride metabolism. Carriers of the I148M allele of the PNPLA3 gene have a higher fat content in the liver and an increased risk of developing steatohepatitis, fibrosis, and liver cirrhosis. The study is intended for diagnosing the transition from steatosis to steatohepatitis in patients with NAFLD.
Period of execution
Within 10 days. The specified time does not include the day of biomaterial collection
Biomaterial type