Description
An investigation allowing the determination of all main parameters of the blood coagulation system.
The study of prothrombin using Quick's method reflects its activity as a percentage of the reference activity in normal plasma solutions. INR (International Normalized Ratio) is a unified indicator calculated based on the prothrombin time value and the International Sensitivity Index of thromboplastin. The International Normalized Ratio is recommended by the World Health Organization as a reference test for dose adjustment and efficacy assessment of anticoagulant therapy.
Fibrinogen is one of the components of the blood coagulation system (coagulation factor I). It is a glycoprotein - a monomer of fibrin. It is synthesized in the liver. After activation by thrombin and conversion into fibrin, it precipitates, forming a blood clot along with other components. The level of fibrinogen in the blood has diagnostic value in pathologies of the blood coagulation system, inflammatory processes, liver pathology, pregnancy monitoring, and diseases of the cardiovascular system. Antithrombin III is a glycoprotein belonging to the blood anticoagulant system, inhibiting thrombin and other hemostasis system factors (X, XII, IX). It is a heparin synergist. It is synthesized in the vascular endothelium and the liver.
APTT is the activated partial thromboplastin time – the time of clot formation in citrated platelet-poor plasma after adding a suspension of synthetic phospholipids with microcrystalline silicon and CaCl2. The analysis simulates the blood coagulation process via the intrinsic pathway, allowing evaluation of the functional integrity of clotting factors participating in this process (XII, XI, IX, VIII, X, V, II). The diagnostic significance of this test lies in the detection, in combination with other studies, of such pathological conditions as hemophilia A and B, liver protein-synthetic insufficiency, disseminated intravascular coagulation syndrome, systemic lupus erythematosus, vitamin K deficiency, and antiphospholipid syndrome. It is also used to monitor heparin therapy.
D-dimer is a degradation product of fibrin, one of the components of a thrombus. It belongs to the indicators characterizing the fibrinolytic (plasmin) system of the blood. Fibrinolysis is the process of splitting a fibrin clot. The D-dimer level in the blood has diagnostic significance in diseases such as deep vein thrombosis, pulmonary embolism, and hereditary coagulopathies. This indicator is important during thrombolytic therapy and pregnancy pathology. An increase in D-dimer levels is observed normally in persons over 80 years of age.
Period of execution
By 00:00 the next day. The specified time does not include the day of biomaterial collection
Biomaterial type