Description
Cortisol (hydrocortisone) is a steroid hormone belonging to the class of glucocorticoid hormones. It is produced by the zona fasciculata of the adrenal cortex. A biological metabolite of cortisol is 6-β-hydroxycortisol, which is formed in the liver under the action of the isoenzyme CYP3A4, localized in the liver and in the cells of the small intestine. The main processes of biotransformation of xenobiotics, including drugs, occur in the liver with the participation of enzymes of the cytochrome P450 system, in particular the isoenzyme CYP3A4. In clinical practice, the cortisol/cortisone ratio is used to indirectly assess the activity of the 11-hydroxysteroid dehydrogenase system (11α-HSD and 11β-HSD), and the 6-hydroxycortisol/cortisol ratio is used to determine the activity of the isoenzyme CYP3A4. Determination of cortisol also has independent diagnostic value.
Determined parameters:
Cortisol
Cortisone (clinically significant in calculating the cortisol/cortisone ratio)
6-Hydroxycortisol
Ratios:
Cortisol/Cortisone
6-Hydroxycortisol/Cortisol
Period of execution
Within 8 days. The specified time does not include the day of biomaterial collection