Description
Methemoglobin (MetHb) is a variant of hemoglobin formed during the transition of ferrous iron to ferric iron. As a result, heme loses its ability to bind to oxygen and transport oxygen to tissues, which leads to the development of hypoxia. Methemoglobin formation occurs at the site of bruises, as well as upon contact of blood with air (blood collection, hematuria). Daily, about 0.5% of hemoglobin in the blood is converted into methemoglobin; however, its concentration in the blood normally does not exceed 1%. Under the influence of methemoglobin reductase involving NADH2, it is converted back into hemoglobin. The occurrence of methemoglobinemia can be associated with congenital factors (hereditary methemoglobinemia) or with the influence of toxic substances or drugs that increase the concentration of methemoglobin. Acquired forms are significantly more common compared to congenital methemoglobinemia.
Period of execution
Within 5 days. The specified time does not include the day of biomaterial collection
Biomaterial type