Detection of 657del5 mutation in the NBS1 gene

The c.657del5 mutation in the NBS1 gene is found in patients at high risk of developing breast cancer in adulthood, including familial forms of cancer. The prevalence of the c.657del5 mutation in the NBS1 gene ranges from 0.2 to 3.7% of affected patients. In addition, the presence of this mutation increases the risk of developing other types of cancer: colorectal cancer, melanoma, prostate cancer, non-Hodgkin lymphoma, as well as acute lymphoblastic leukemia in children.

Within 12 days