Ostase

Ostase is the bone isoenzyme of alkaline phosphatase (BAP, bone alkaline phosphatase). It is a marker of bone metabolism. In metabolic bone diseases, alkaline phosphatase activity correlates with the level of bone tissue formation. The specificity of BAP, as well as its half-life in the blood (1-2 days) and lack of metabolism in the liver/excretion by kidneys, make it a near-ideal marker for osteoblast activity. Quantitative determination of BAP provides useful information about bone remodeling in patients with osteoporosis and Paget's disease, as well as about changes in disease activity under the influence of antiresorptive therapy during the treatment of postmenopausal osteoporosis.

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