Description
One of the most important components of the complement system, participating in the reactions of the classical activation pathway. Deficiency of the C4 component leads to the development of an autoimmune disease identical in symptoms and manifestations to systemic lupus erythematosus (SLE) and characterized by the deposition of immune complexes in the kidneys, skin, and blood vessels. However, the development of SLE due to severe C4 deficiency is extremely rare, as it requires mutations in two different genes coding for protein subunits. Mutations in one of the genes create a predisposition to the development of SLE, which occurs much more frequently.
Indications:
1. Diagnosis of predisposition to systemic lupus erythematosus
2. Monitoring of autoimmune diseases
3. Assessment of immune status in infectious diseases
Related tests:
[20-043] Complement C1 inhibitor
Period of execution
Within 4 days
Biomaterial type