Description
IgG is the main component of the gamma-globulin fraction of serum proteins. It constitutes up to 70% of the immunoglobulin pool. Secretion is performed mainly by plasma cells. Class G immunoglobulins include the principal antibodies of the secondary immune response and all antitoxin immunoglobulins. In the body, they perform toxin-neutralizing, virus-neutralizing, and bactericidal functions. Class G immunoglobulins are the only immunoglobulins capable of crossing the placenta.
Elevated levels are observed in: acute and chronic bacterial, parasitic, and fungal infections; acute and chronic liver diseases (viral hepatitis, cirrhosis); systemic connective tissue disorders (systemic lupus erythematosus, rheumatoid arthritis, rheumatism, collagenoses); diseases of the blood system (chronic lymphocytic leukemia, multiple myeloma, Waldenström macroglobulinemia); infectious mononucleosis, cystic fibrosis, sarcoidosis, AIDS.
Decreased levels are possible in: immunodeficiency states (hereditary hypogammaglobulinemia or agammaglobulinemia and combined immunodeficiency), hemoglobinopathies, prolonged protein loss in renal and intestinal pathology, chronic infection, after splenectomy.
Indications for testing:
1. Diagnosis and differential diagnosis of acute bacterial, parasitic, viral, and fungal infections
2. Diagnosis of immunodeficiency states
3. Diagnosis of systemic connective tissue diseases
4. Diagnosis of blood system diseases
Additional testing of IgM, IgE, IgA, leukocytes, lymphocytes, ESR, and acute-phase markers is also recommended.
Period of execution
By 00:00 the next day. The specified time does not include the day of biomaterial collection
Biomaterial type