Description
Vitamin B1 (thiamine) belongs to the group of water-soluble vitamins. Thiamine is necessary for the synthesis of acetylcholine – one of the main neurotransmitters – substances required for the conduction of nerve impulses. It also participates in the utilization of pyruvic and lactic acids. It acts as an antioxidant. Although thiamine is synthesized by the intestinal microflora, the main amount of the vitamin comes from food products. Unpolished rice, nuts, prunes, and brewer's yeast are richest in thiamine. In the human body, thiamine converts into an active form – thiamine pyrophosphate, the formation of which requires the presence of magnesium ions.
Thiamine deficiency causes the development of a number of severe disorders, leading among which are nervous system lesions known as beriberi disease.
With a lack of thiamine, a disorder of oxidative decarboxylation of α-keto acids primarily occurs, and carbohydrate metabolism is partially blocked.
In patients with beriberi, there is an accumulation of under-oxidized pyruvate metabolism products, which have a toxic effect on the CNS and cause the development of metabolic acidosis. Due to the development of energy deficiency, the function of nerve and muscle tissue cells is primarily impaired. The synthesis of fatty acids and the transformation of carbohydrates into fats are disrupted. Increased protein catabolism leads to the development of muscular atrophy in adults, and physical development retardation in children.
Period of execution
Within 6 days. The specified time does not include the day of biomaterial collection
Biomaterial type